The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might cause an increase in methadone plasma concentrations, which could result in probably deadly respiratory despair. Also, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers might also lead to an increase in met